A lorry has fallen approximately 60m from the M6 motorway, near the Thelwall Viaduct.
It is understood there is one casualty, the driver of the vehicle, whose injuries are not thought to be life threatening.
Cheshire Fire and Rescue Service said they were called to the incident on Monday evening at about 7pm.
Five fire engines were in attendance – from Warrington, Lymm, Middlewich, Chester and Powey Lane – plus a rescue boat from Warrington and an aerial appliance from Lymm.
“Firefighters were called to reports of a heavy goods vehicle (HGV) that had left the carriageway of the M6 northbound between Junction 20 and 21, close to the Thelwall Viaduct,” a spokesperson for the fire service said.
“On arrival, they found that a HGV had left the carriageway and overturned on an embankment, falling approximately 60m.
“Crews used technical rescue equipment to lower themselves and reach the casualty, who was handed over to the care of attending paramedics.”
They added that crews used water to cool the HGV and bunding to contain a leak of approximately 1,000 litres of bio-diesel from the fuel tanks of the vehicle.
A spokesperson for Cheshire Police said: “Shortly after 6.50pm on Monday 30 September, police were called to reports of an incident on the M6 northbound at Thelwall Viaduct, between junction 20 and 21.”
They said lanes were closed on the northbound carriageway due to serious damage to the barrier.
One lane would remain open with a reduced speed limit, they added.
Police said the lane closures were expected to continue into Tuesday morning.
Motorists were advised to avoid the area and find an alternative route.
